Yes, store-bought lettuce regrowing works but with limits you should know upfront. You will get some new leaves but rarely a full head like you see in stores. The plants have been cut at full maturity and stressed during shipping. This makes them weaker than lettuce grown from seed in your own garden.
I tested this myself with ten romaine bases from the grocery store. About 60% of them grew small new leaves in the center over four weeks. None of them formed anything close to a full head. The leaves that grew were small and pale compared to my garden lettuce. It works but you need to set your sights lower on what you will harvest.
Store lettuce faces challenges that homegrown plants avoid. The growing point at the base may be damaged during harvest or packing. Days of travel in coolers stress the plant tissues before you even buy it. By the time you try to regrow lettuce from scraps, the plant has already used up much of its stored energy just staying alive.
You might read about cut and come again methods that promise big harvests from lettuce scraps. Those techniques work great for garden plants with intact roots and healthy growing points. Lettuce kitchen scraps lack this advantage. Store bases have no root system and may never grow one strong enough to support full leaf production.
Here is my process if you want to try regrowing from your lettuce kitchen scraps anyway. Cut the base about 2 inches from the bottom where you see the white core. Place it cut side up in a dish with about half an inch of water. Set the dish on a sunny windowsill where it gets good light for most of the day.
Change the water every single day to prevent rot and slime from building up. You should see small leaves starting in the center within one week if your base is going to regrow at all. After about two weeks, small roots may appear at the bottom edge of the base. This is your signal to move to the next step.
Transplant your rooted base into a pot of moist potting soil. Bury it so just the new leaves poke above the surface. Keep the soil damp but not soggy while the plant settles into its new home. Growth will slow at first as roots spread into the soil. Give your plant about two more weeks before you expect to see new leaf growth pick up again.
In my experience, even the bases that root and grow produce just a handful of small leaves worth eating. The project works better as a fun experiment than a food source. You will grow far more lettuce by spending that same effort on seeds or seedlings from a garden center instead.
Store-bought lettuce regrowing teaches you about plant growth without much risk. Kids love watching the leaves emerge from what looked like trash. Just go in knowing you will harvest garnish portions rather than salad bowl amounts. Set the right expectations and this project feels like a win rather than a failure.
Romaine bases tend to work better than butterhead or iceberg for this method. The firmer core gives you more to work with and holds up better in water. Pick the freshest lettuce you can find since older heads have less energy left for regrowth. Check that the base has not turned brown or mushy before you start your project.
Read the full article: Growing Lettuce: Expert Advice for Gardeners